Actinic keratosis signs and symptoms
How does actinic keratosis affect the skin?

Chronic exposure to ultraviolet (UV) radiation from the sun and other sources causes excessive multiplication of keratinocytes, the main cells of the epidermis (the outermost layer of the skin).
These keratinocytes also undergo alterations and become atypical, that is different from normal ones. The result is a localized skin lesion that is seen as a thick, rough and scaly patch, also known as actinic keratosis or solar keratosis.
Actinic keratoses are, in short, lesions appearing in sun-damaged skin. Most frequently, not only is the area where the lesion appears damaged, but the surrounding region is also damaged as well, exhibiting a yellowish colour, with spots or even small broken blood vessels. Other times, this area of surrounding skin looks normal, but when examined under a microscope or by molecular techniques, abnormalities are identified. This area is called field of cancerization.
What do actinic keratoses look like?
At first actinic keratoses can be hard to see with the naked eye, but they can be easily felt as small areas of rough, dry or flaky skin.

As they progress, actinic keratoses usually appear as plaques or scabs between 1 and 3 millimetres in diameter but can grow to several centimetrers in size. Actinic keratosis lesions can take different forms and colours, even in the same person. They can also present as single individual lesions or clustered in areas exposed to sunlight.

As we have said, the surrounding skin may also have a yellowish appearance or have spots or small broken blood vessels.
- Patches of scaly spots similar to a rash or acne.
- Flat and flaky area that resembles an age spot.
- Skin horn shape. It is usually hard and has a conical appearance.

In the lips, actinic keratosis can also manifest as:
- Dry, scaly patches on the lips that do not heal.
- Presence of white, scaly plaques.
- Loss of colour.
References
- De Berker, D., McGregor, J.M., Mohd Mustapa, M.F., Exton, L.S., Hughes, B.R. British Association of Dermatologists’ guidelines for the care of patients with actinic keratosis 2017. Br J Dermatol [Internet]. 2017 Jan 18 [cited 2020 Feb 19]; 176(1):20-43. Available at: https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.15107
- Werner RN, Stockfleth E, Connolly SM, et al. Evidence- and consensus-based (S3) Guidelines for the Treatment of Actinic Keratosis - International League of Dermatological Societies in cooperation with the European Dermatology Forum - Short version [Internet]. J Eur Acad Dermatol Venereol. 2015;29(11):2069-79. Available at: http://doi.wiley.com/10.1111/jdv.13180
- Moy, R.L. Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol [Internet]. 2000 Jan [cited 2020 feb 20];42(1 Suppl. 1):S8–10. Available at: https://www.jaad.org/article/S0190-9622(00)27494-X/fulltext. doi.10.1067/mjd.2000.103343.
- British Association of Dermatologists (BAD). Actinic Keratoses - Also Known as Solar Keratoses [Internet]. 2007 May [revised 2019 Nov; cited 2020 Feb 19]; 5 p. Available at: http://www.bad.org.uk/shared/get-file.ashx?id=66&itemtype=document
- Skin Cancer Foundation. Actinic Keratosis Warning Signs [Internet]. 2019 May [cited 2020 Feb 19]; approx. 5 screens. Available at: https://www.skincancer.org/skin-cancer-information/actinic-keratosis/actinic-keratosis-warning-signs-and-images/
- American Academy of Dermatology (AAD). Actinic keratosis: signs and symptoms [Internet]. 2020 [cited 2020 Feb 19]; approx. 5 screens. Available at: https://www.aad.org/public/diseases/skin-cancer/actinic-keratosis-symptoms
